Latest Release - April 17, 2025

New Publications (6)

PGS Publication/Study ID (PGP)	PGS Developed	PGS Evaluated	First Author	Title	Journal Name	Publication Date	Digital object identifier (doi)	PubMed ID (PMID)
PGP000719	1	1	Dai L	Diabetes status, genetic susceptibility, and incident arrhythmias: A prospective cohort study of 457,151 participants.	Diabetes Metab Syndr	01/03/2024	10.1016/j.dsx.2024.102971	38458077
PGP000720	0	2	Masip G	Plant-based dietary patterns and genetic susceptibility to obesity in the CARTaGENE cohort.	Obesity (Silver Spring)	06/12/2023	10.1002/oby.23944	38057558
PGP000721	0	6	Sadler MC	Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications.	Nat Commun	25/03/2025	10.1038/s41467-025-58152-3	40133288
PGP000722	0	1	Yuan S	Digestive System Diseases, Genetic Risk, and Incident Dementia: A Prospective Cohort Study.	Am J Prev Med	31/10/2023	10.1016/j.amepre.2023.10.017	37918457
PGP000718	1	1	D'Aoust T	Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification.	Alzheimers Dement	01/03/2025	10.1002/alz.70014	40042447
PGP000691	1	1	Lee DSM	Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.	Nat Genet	07/04/2025	10.1038/s41588-025-02140-2	40195560

New Polygenic Scores (3)

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Individuals included in:

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G - Source of Variant Associations (GWAS)

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E - PGS Evaluation

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Polygenic Score ID & Name	PGS Publication ID (PGP)	Reported Trait	Mapped Trait(s) (Ontology)	Number of Variants	Ancestry distribution GWAS Dev Eval	Scoring File (FTP Link)
PGS005097 (prscsx_meta_HF)	PGP000691 | Lee DSM et al. Nat Genet (2025)	Heart failure	heart failure	1,274,692	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005097/ScoringFiles/PGS005097.txt.gz
PGS005170 (iPRS_DEM)	PGP000718 | D'Aoust T et al. Alzheimers Dement (2025)	All-cause dementia	dementia	1,320,229		https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005170/ScoringFiles/PGS005170.txt.gz
PGS005171 (PRS142_AF)	PGP000719 | Dai L et al. Diabetes Metab Syndr (2024)	Atrial fibrillation	atrial fibrillation	142	-	https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005171/ScoringFiles/PGS005171.txt.gz