Polygenic Score (PGS) ID: PGS005205

Predicted Trait
Reported Trait Prostate cancer
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Released in PGS Catalog: May 20, 2025
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Score Details

Score Construction
PGS Name PRS130_Pca
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 130
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000726
Citation (link to publication) Benafif S et al. BJU Int (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
140,254 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006085
Europe PMC: 29892016
 140,254 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022572 PSS012021|
European Ancestry|
297 individuals
 PGP000726 |
Benafif S et al. BJU Int (2021)
 Reported Trait: prostate cancer — — Percentage of screened individuals diagnosed with cancer: 38.9 % — Threshold (90th centile) = 11.15
PPM022590 PSS012025|
European Ancestry|
6,393 individuals
 PGP000730 |
McHugh JK et al. N Engl J Med (2025)
|Ext.		 Reported Trait: clinically significant prostate cancer in screened individuals OR: 1.98 [0.98, 4.03] AUROC: 0.55 [0.49, 0.61] Percent of screened particpants diagnosed with cancer: 40.0 %
Percent of diagnosed cancers identified as intermediate or high risk: 55.1 %		 — —
PPM022591 PSS012025|
European Ancestry|
6,393 individuals
 PGP000730 |
McHugh JK et al. N Engl J Med (2025)
|Ext.		 Reported Trait: clinically significant prostate cancer in screened individuals OR: 2.24 [1.08, 4.65] — — Age, Family History, one of (PSA, PIRADS) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012025 "745 (11.7%) had a polygenic risk score in the 90th percentile or higher and were invited to undergo screening." — 6,393 individuals,
100.0 % Male samples
 — European — NR —
PSS012021 — — 297 individuals,
100.0 % Male samples
 — European — BARCODE1 —